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all in pdf form. If you download them they may still be able to tell you from where you downloaded them. They.Cyclosporin A in recurrent hepatitis C after liver transplantation: a new hope? Routine use of cyclosporin A (CsA) in liver transplantation is well established, although its role in the management of recurrent hepatitis C is unknown. Retrospective review of a single transplant centre's experience with CsA use to treat recurrent hepatitis C after liver transplantation. Twelve liver transplant recipients with recurrent hepatitis C underwent treatment with CsA between 2000 and 2005. Baseline serum HCV RNA was detectable in 10 patients (83%), and for six of these, infection was genotype 1. Six of these six patients received CsA for treatment of recurrent disease. With a mean follow-up period of 41.3 months, three of these six patients had undetectable serum HCV RNA (sustained virological response) with no re-infection. The two other patients, who had detectable s-HCV RNA at baseline, had higher viral load (10.8 and 9.8 log copies/ml) and did not respond to CsA therapy. Furthermore, the viral load of the patient in whom CsA was not continued, increased from 5.7 to 9.4 log copies/ml. There were no significant side-effects from CsA therapy. CsA may be effective and well-tolerated in the treatment of recurrent hepatitis C after liver transplantation.High frequency of high density lipoprotein cholesterol depression in familial combined hyperlipidaemia. A significant decline of HDL-cholesterol occurs in treated patients with familial combined hyperlipidaemia (FCH). In this study, we examined whether or not this fall is associated with the degree of hyperlipidaemia. Forty-six patients were studied. Of these, 26 were FCH, 16 had hypercholesterolaemia with a tendency towards elevated LDL cholesterol, 8 hypertriglyceridaemia and 14 had hypertriglyceridaemia combined with reduced HDL-cholesterol. At baseline the serum triglyceride levels were lower in FCH patients than in the other groups. The HDL-cholesterol levels were lower in hyperlipidaemic patients with FCH than in those without this disorder. No significant changes in the other variables were observed between the various groups. Following treatment with gemfibrozil, the HDL-cholesterol levels increased significantly
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